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KMID : 1134820120410040443
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 4 p.443 ~ p.449
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Antioxidant Activities and Acetylcholinesterase Inhibitory Activities from Seaweed Extracts
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Jeon Young-Eun
Yin Xing-Fu
Lim Soon-Sung
Chung Cha-Kwon
Kang Il-Jun
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Abstract
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This study was conducted to investigate the antioxidant and acetylcholinesterase (AChE) inhibitory activities of extracts from various seaweed. The extracts of Sargassum thunbergii (91.3%), Polysiphonia morrowii (90.7%), Ecklonia cava (89.9%), and Artemisia fukudo (85.9%) showed over 80% high radical scavenging activities at the final concentration of 40 μg/mL. The Artemisia fukudo extract showed the highest inhibition activity of 30.2% on AChE at the final concentration of 10 μg/mL. The extract of Porphyra tenera, Costaria costata, Monostroma nitidum, Ecklonia cava, and Agarum clathratum against AChE at a concentration of 10 μg/mL exhibited inhibition of 26.6%, 25.3%, 23.4%, 21.7%, 20.4% and 19.9%, respectively. The bioautography results showed that the mixtures of structurally diverse compounds were thought to affect AChE inhibitory activity. These results suggest that extracts from seaweed with their high quality components may be effective in the prevention of Alzheimer's disease and may be used to develop various functional food products.
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KEYWORD
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seaweed, Alzheimer
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